Oprah Winfrey is scheduled to sit down for the entire show with Julie Chen, Sara Gilbert, Sharon Osbourne, Aisha Tyler and Sheryl Underwood on The Talk, Monday, April 17 (2:00-3:00 PM, ET/1:00-2:00 PM, PT/CT) on the CBS Television Network.

During her first visit to the show, Winfrey will discuss her new HBO film, The Immortal Life of Henrietta Lacks. The film is told through the eyes of Deborah Lacks (played by Winfrey) who learns about the mother she never knew, Henrietta Lacks, and how the unauthorized harvesting of her mother’s cancerous cells in 1951 led to unprecedented medical breakthroughs that changed the face of medicine forever.

Also, she will talk about her new role as a special correspondent on the #1 news broadcast on television, 60 Minutes, on CBS and share intimate stories from behind the scenes of her award-winning talk show of 25 years, “The Oprah Winfrey Show.”

CBS’s Daytime Emmy Award-winning talk show The Talk features a panel of well-known news and entertainment personalities discussing current events, pop culture, contemporary issues, family, celebrity and the trending topics of the day. The daily one-hour series is hosted by Julie Chen, Sara Gilbert, Sharon Osbourne, Aisha Tyler and Sheryl Underwood. The hosts swap stories, challenge each other on issues and engage the studio audience and viewers at home about events in the headlines and their own homes. Show segments include guest interviews with entertainers and newsmakers, musical performances, cooking demos with celebrity chefs, as well as real-world advice. Multiple Daytime Emmy Award-winning John Redmann serves as executive producer. Gilbert, who developed the show, is also an executive producer. Heather Gray and Kristin Matthews are co-executive producers.